Stroke is divided into ischemic (87%) and hemorrhagic (13%). Ischemic stroke occurs immediately after the blockage (embolization) of the cerebral artery.
In the USA, there are about 750,000 new cases per year, while in Russia, about 400,000. Mortality in the first month is 15-30%. The surviving part constitutes a major problem for the patient, the family, society, and the healthcare system.
The brain constitutes only 2% of body weight, but consumes 20% of oxygen. If it remains without blood for 5-8 minutes, it suffers irreversible damage: anoxia, edema, neuron death (loss of 1.9 million neurons/minute). Therefore, the sooner the treatment starts, the better the prognosis. Ideally, it should start within the first 90 minutes.
Even in the area surrounding the stroke (penumbra), within a few hours, progressive damage characterized by progressive hypoxia, glucose deficiency, increased lactic acid, edema, reduction of intracellular ATP, inhibition of protein synthesis, including neurotransmitters, occurs. If we do not intervene in time, this wider area suffers irreversible damage.
With the discovery of Tissue Plasminogen Activator (TPA), hopes were raised that by quickly dissolving the thrombus and reopening circulation, neuronal damage would be limited.
However, thrombolysis has its own limitations:
The "golden time" to save the nerve tissue in the penumbra is 5-12 hours (Prof. V.Bocci). According to Wasser, it extends up to 48 hours (if ozone therapy is given after 48 hours, it cannot avoid paralysis).
The goal of the therapy is to re-oxygenate the penumbra as quickly as possible, to reduce the edema in the brain tissue. This is achieved with ozone therapy, which:
A. Ischemic stroke treated conventionally (irregular appearance of brain tissue)
B. Ischemic stroke treated with ozone therapy (regular appearance of brain tissue)
MRI images of the head: see the significant difference between a case treated conventionally (A) and another treated with ozone therapy (B)
Treatment: combines one of the systemic application forms of ozone (AHTma, FO, RI) with conventional therapy (nootropics, Ca-blockers, vitamins, antiplatelets, physiotherapy, etc.)
Positive results are seen after the first sessions:
Some practical advice: